Its main activity is the conduct of authorised payments under the federal budget, and the other that in accordance with the laws, agreements, contracts and other legal provisions, are issued by the various areas of the university management; as well as the control of the financial resources of this maximum house of studies.

Among its main functions are the following:

- To develop SPEI of economic operations with the third parties to which the university has a commercial relationship.

- To develop checks from those operations that would warrant payment to suppliers.

- To request account statements for its proper posting.

- To perform openings and closure of bank accounts upon authorization by the Secretary of Finance and the Dean.

The head of the Expenses Office is  C. Raymundo Rommel Regalado Hernández.